Thank you for your tireless research and help to awaken humanity! I went searching my own archives for information on adjuvants and came across this gem. GO - aka hydrogel, aka Black Goo - is considered a vaccine adjuvant. Felt it important to share with you. https://pubmed.ncbi.nlm.nih.gov/32531395/
Abstract
Vaccine is one of the most effective strategies for preventing and controlling infectious diseases and some noninfectious diseases, especially cancers. Adjuvants and carriers have been appropriately added to the vaccine formulation to improve the immunogenicity of the antigen and induce long-lasting immunity. However, there is an urgent need to develop new all-purpose adjuvants because some adjuvants approved for human use have limited functionality. Graphene oxide (GO), widely employed for the delivery of biomolecules, excels in loading and delivering antigen and shows the potentiality of activating the immune system. However, GO aggregates in biological liquid and induces cell death, and it also exhibits poor biosolubility and biocompatibility. To address these limitations, various surface modification protocols have been employed to integrate aqueous compatible substances with GO to effectively improve its biocompatibility. More importantly, these modifications render functionalized-GO with superior properties as both carriers and adjuvants. Herein, the recent progress of physicochemical properties and surface modification strategies of GO for its application as both carriers and adjuvants is reviewed. STATEMENT OF SIGNIFICANCE: Due to its unique physicochemical properties, graphene oxide is widely employed in medicine for purposes of photothermal treatment of cancer, drug delivery, antibacterial therapy, and medical imaging. Our work describes the surface modification of graphene oxide and for the first time summarizes that functionalized graphene oxide serves as a vaccine carrier and shows significant adjuvant activity in activating cellular and humoral immunity. In the future, it is expected to be introduced into vaccine research to improve the efficacy of vaccines.
Declaration of Competing Interest Financial support from International Cooperation and Exchange Program of Science and Technology Department of Sichuan Province (No. 2018HH0114), Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital clinical study and translational fund (No. 2020LZ01), University of Electronic Science and Technology of China Central University Basic Research Expenses Project (No. 2672018ZYGX2018J101) and Sichuan Science and Technology Program (No. 2020YFG0100).
Similar articles
Alum-functionalized graphene oxide nanocomplexes for effective anticancer vaccination.
Wang X, et al. Acta Biomater. 2019. PMID: 30448435
Functionalized graphene oxide serves as a novel vaccine nano-adjuvant for robust stimulation of cellular immunity.
Xu L, et al. Nanoscale. 2016. PMID: 26814441
Graphene Oxides Decorated with Carnosine as an Adjuvant To Modulate Innate Immune and Improve Adaptive Immunity in Vivo.
Meng C, et al. ACS Nano. 2016. PMID: 26766427
Better Adjuvants for Better Vaccines: Progress in Adjuvant Delivery Systems, Modifications, and Adjuvant-Antigen Codelivery.
Wang ZB, et al. Vaccines (Basel). 2020. PMID: 32183209 Free PMC article. Review.
Adjuvants and delivery systems based on polymeric nanoparticles for mucosal vaccines.
Jin Z, et al. Int J Pharm. 2019. PMID: 31669213 Review. I can't attach links here, but I have multiple PubMed links showing GO used as adjuvants in treating cancer and multiple articles about immune modulation and as a delivery system. Use PubMed with search terms: Adjuvant delivery, Antigen delivery, Functionalized-GO, Immune adjuvant, and Vaccine nano-carrier.
I used to get the flu shot every year. And I would get the flu every year. Perhaps 30 years ago, a little light bulb went on in my head and I finally realized the correlation. So I stopped getting the flu shot and I have not had the flu since.
Since that time, I have done a lot of reading about vaccines. My conclusion: the entire science behind vaccines is based on false premises and outright lies. It is far more intended to create massive revenue for Big Pharma than to improve anyone's health. In fact, many studies I have read that have compiled data over decades have concluded that children (and adults) who routinely take vaccines are considerably less healthy overall than those who avoid all vaccines. Unsurprisingly, this information is suppressed as much as possible.
My solution to this: eat healthy, take supplements known to boost the immune system, and AVOID ALL VACCINES. I am 70 and doing just fine.
VACCINE EXCIPIENT SUMMARY - Excipients Included in U.S. Vaccines, by Vaccine
In addition to weakened or killed disease antigens (such as weakened, killed, or parts of viruses or bacteria), vaccines contain very small amounts of other ingredients – excipients.
Some excipients are added to a vaccine for a specific purpose. These include:
- Preservatives, to prevent contamination. For example, thimerosal.
- Adjuvants, to help stimulate a stronger immune response. For example, aluminum salts.
- Stabilizers, to keep the vaccine potent during transportation and storage. For example, sugars or gelatin.
thers are residual trace amounts of materials that were used during the manufacturing process and removed.
These can include:
- Cell culture materials, used to grow the vaccine antigens. For example, egg protein, various culture media.
- Inactivating ingredients, used to kill viruses or inactivate toxins. For example, formaldehyde.
- Antibiotics, used to prevent contamination by bacteria. For example, neomycin.
Example : DTaP-IPV (Kinrix) 01/2021(b) formaldehyde, aluminum hydroxide, sodium chloride, polysorbate 80 (Tween 80), neomycin sulfate, polymyxin B
We learned all about adjuvants in animal vaccines in veterinary medicine. I was a registered veterinary technician for 24+ years and I still have my license. It's disturbing that the people giving all these human vaccines of every type, know nothing about what's in them. And immune response to a foreign substance injected into the body does not correlate with protection against any disease. Antibodies are non-specific and are produced for a variety of reasons, none of which are for "viruses" . We have been lied to about everything since the time of Louis Pasteur. Question everything.
"There will be violent earthquakes and in various places famines and [deadly and devastating] pestilences (plagues, epidemics); and there will be terrible sights and great signs from heaven." Luke 21:11 AB
Thank you, Dr. T, for the excellent research about what real medical science has to say about our current Vaccines, and for sounding the much-needed warning alarm to stay awake or be harmed!
Terrifying that these crazy scientists and the big pharma mafia inject their toxic shit into humanity without any punishment for the harm they are causing! Great business model though - inject everyone with toxic life saving vaccines and then sell medications to you to deal with the damage they cause to you!!!
Wiser to attend a Homeopathic Doctor never using the POISONS of the Allopaths connected to the shark Pharma laundering $$$ from everybody for their own gain and that of their Masters in The City of London to continue purchasing the Corporate/Prostitute Politicians and Deep State Minions with the Indirect Support through academia and Media. TOTAL DEATH CULT CRIME SYNDICATE.
“Medical science” is getting stupider and stupider.
I was writing to say You remain in my prayers Dr. T. Hope God will soon heal you.
dolores
Thank you for your tireless research and help to awaken humanity! I went searching my own archives for information on adjuvants and came across this gem. GO - aka hydrogel, aka Black Goo - is considered a vaccine adjuvant. Felt it important to share with you. https://pubmed.ncbi.nlm.nih.gov/32531395/
Abstract
Vaccine is one of the most effective strategies for preventing and controlling infectious diseases and some noninfectious diseases, especially cancers. Adjuvants and carriers have been appropriately added to the vaccine formulation to improve the immunogenicity of the antigen and induce long-lasting immunity. However, there is an urgent need to develop new all-purpose adjuvants because some adjuvants approved for human use have limited functionality. Graphene oxide (GO), widely employed for the delivery of biomolecules, excels in loading and delivering antigen and shows the potentiality of activating the immune system. However, GO aggregates in biological liquid and induces cell death, and it also exhibits poor biosolubility and biocompatibility. To address these limitations, various surface modification protocols have been employed to integrate aqueous compatible substances with GO to effectively improve its biocompatibility. More importantly, these modifications render functionalized-GO with superior properties as both carriers and adjuvants. Herein, the recent progress of physicochemical properties and surface modification strategies of GO for its application as both carriers and adjuvants is reviewed. STATEMENT OF SIGNIFICANCE: Due to its unique physicochemical properties, graphene oxide is widely employed in medicine for purposes of photothermal treatment of cancer, drug delivery, antibacterial therapy, and medical imaging. Our work describes the surface modification of graphene oxide and for the first time summarizes that functionalized graphene oxide serves as a vaccine carrier and shows significant adjuvant activity in activating cellular and humoral immunity. In the future, it is expected to be introduced into vaccine research to improve the efficacy of vaccines.
Keywords: Adjuvant delivery; Antigen delivery; Functionalized-GO; Immune adjuvant; Vaccine adjuvant; Vaccine nano-carrier.
Copyright © 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Conflict of interest statement
Declaration of Competing Interest Financial support from International Cooperation and Exchange Program of Science and Technology Department of Sichuan Province (No. 2018HH0114), Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital clinical study and translational fund (No. 2020LZ01), University of Electronic Science and Technology of China Central University Basic Research Expenses Project (No. 2672018ZYGX2018J101) and Sichuan Science and Technology Program (No. 2020YFG0100).
Similar articles
Alum-functionalized graphene oxide nanocomplexes for effective anticancer vaccination.
Wang X, et al. Acta Biomater. 2019. PMID: 30448435
Functionalized graphene oxide serves as a novel vaccine nano-adjuvant for robust stimulation of cellular immunity.
Xu L, et al. Nanoscale. 2016. PMID: 26814441
Graphene Oxides Decorated with Carnosine as an Adjuvant To Modulate Innate Immune and Improve Adaptive Immunity in Vivo.
Meng C, et al. ACS Nano. 2016. PMID: 26766427
Better Adjuvants for Better Vaccines: Progress in Adjuvant Delivery Systems, Modifications, and Adjuvant-Antigen Codelivery.
Wang ZB, et al. Vaccines (Basel). 2020. PMID: 32183209 Free PMC article. Review.
Adjuvants and delivery systems based on polymeric nanoparticles for mucosal vaccines.
Jin Z, et al. Int J Pharm. 2019. PMID: 31669213 Review. I can't attach links here, but I have multiple PubMed links showing GO used as adjuvants in treating cancer and multiple articles about immune modulation and as a delivery system. Use PubMed with search terms: Adjuvant delivery, Antigen delivery, Functionalized-GO, Immune adjuvant, and Vaccine nano-carrier.
So thankful for this information!
I used to get the flu shot every year. And I would get the flu every year. Perhaps 30 years ago, a little light bulb went on in my head and I finally realized the correlation. So I stopped getting the flu shot and I have not had the flu since.
Since that time, I have done a lot of reading about vaccines. My conclusion: the entire science behind vaccines is based on false premises and outright lies. It is far more intended to create massive revenue for Big Pharma than to improve anyone's health. In fact, many studies I have read that have compiled data over decades have concluded that children (and adults) who routinely take vaccines are considerably less healthy overall than those who avoid all vaccines. Unsurprisingly, this information is suppressed as much as possible.
My solution to this: eat healthy, take supplements known to boost the immune system, and AVOID ALL VACCINES. I am 70 and doing just fine.
I am grateful for this information that supports my decision to avoid all big pharma products like the plague they are.
VACCINE EXCIPIENT SUMMARY - Excipients Included in U.S. Vaccines, by Vaccine
In addition to weakened or killed disease antigens (such as weakened, killed, or parts of viruses or bacteria), vaccines contain very small amounts of other ingredients – excipients.
Some excipients are added to a vaccine for a specific purpose. These include:
- Preservatives, to prevent contamination. For example, thimerosal.
- Adjuvants, to help stimulate a stronger immune response. For example, aluminum salts.
- Stabilizers, to keep the vaccine potent during transportation and storage. For example, sugars or gelatin.
thers are residual trace amounts of materials that were used during the manufacturing process and removed.
These can include:
- Cell culture materials, used to grow the vaccine antigens. For example, egg protein, various culture media.
- Inactivating ingredients, used to kill viruses or inactivate toxins. For example, formaldehyde.
- Antibiotics, used to prevent contamination by bacteria. For example, neomycin.
Example : DTaP-IPV (Kinrix) 01/2021(b) formaldehyde, aluminum hydroxide, sodium chloride, polysorbate 80 (Tween 80), neomycin sulfate, polymyxin B
https://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/b/excipient-table-2.pdf
US Military development of new Adjuvants is going at a frantic pace.
https://geoffpain.substack.com/p/peter-hotez-promotes-endotoxin-and
Nanoparticles as Adjuvants in Vaccine Delivery for transhuman DNA altering of humans is why everyone should be anti-vax, period.
Everyone reading this important information should share it with at least one other person.
I vowed in 2020 never again to accept another "vaccine." This new info about adjuvants solidifies my resolve.
We learned all about adjuvants in animal vaccines in veterinary medicine. I was a registered veterinary technician for 24+ years and I still have my license. It's disturbing that the people giving all these human vaccines of every type, know nothing about what's in them. And immune response to a foreign substance injected into the body does not correlate with protection against any disease. Antibodies are non-specific and are produced for a variety of reasons, none of which are for "viruses" . We have been lied to about everything since the time of Louis Pasteur. Question everything.
"There will be violent earthquakes and in various places famines and [deadly and devastating] pestilences (plagues, epidemics); and there will be terrible sights and great signs from heaven." Luke 21:11 AB
Thank you, Dr. T, for the excellent research about what real medical science has to say about our current Vaccines, and for sounding the much-needed warning alarm to stay awake or be harmed!
Terrifying that these crazy scientists and the big pharma mafia inject their toxic shit into humanity without any punishment for the harm they are causing! Great business model though - inject everyone with toxic life saving vaccines and then sell medications to you to deal with the damage they cause to you!!!
Maybe next year's COVID variant jab will include Fentanyl and we will be spared seeing all the self-righteous jerks and Moderna ads on television.
Wiser to attend a Homeopathic Doctor never using the POISONS of the Allopaths connected to the shark Pharma laundering $$$ from everybody for their own gain and that of their Masters in The City of London to continue purchasing the Corporate/Prostitute Politicians and Deep State Minions with the Indirect Support through academia and Media. TOTAL DEATH CULT CRIME SYNDICATE.
WE WILL NOT COMPLY 🦅